Abstract Positron emission tomography (PET) systems employ mixed-signal front-end to carry out relatively simple, and ad hoc , processing of the charge pulses generated upon event detection. To obtain, and maintain over time, proper calibrations of the mixed-signal circuitry for generating accurate event information is a challenging task due to the simplicity of the event processing, and the huge number of channels and multiplexing of the input signals found in modern PET systems. It is also difficult to modify or extend the event-processing technologies when needs arise because it would involve making changes to the circuitry. These limitations can be
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